Adding a certain compound to certain chemical reactions, such as: 69034-12-4, 2-Chloro-5-(trifluoromethyl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Chloro-5-(trifluoromethyl)pyrimidine, blongs to pyrimidines compound. name: 2-Chloro-5-(trifluoromethyl)pyrimidine
Under argon protection, the ice water was cooled, and 2-chloro-5-trifluoromethylpyrimidine (19 g, 104 mmol) was added to a 500 mL three-necked flask.Anhydrous tetrahydrofuran (100 mL) and tetrakistriphenylphosphine palladium (4.6 g, 4 mmol),The prepared compound 2 of tetrahydrofuran was poured into a constant pressure dropping funnel.The reaction solution was dropped (maintained at 20 C or lower). The reaction was carried out at room temperature overnight.Under ice bath, slowly add 10% ammonium chloride solution (300 mL) to quench the reaction.Ethyl acetate (300 mL) was added, and the black insoluble material was filtered off with Celite.The aqueous phase was extracted once more with ethyl acetate (200 mL).Wash with saturated brine, dry over anhydrous sodium sulfate, spin dry, sample, and purified by column chromatography.Obtained as a pale yellow liquid, compound 3 (25 g, 95 mmol, 91%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,69034-12-4, 2-Chloro-5-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Jifeng Biological Technology Co., Ltd.; Xu Hongyan; Ma Jingxiang; (4 pag.)CN109988116; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia