Synthetic Route of 19875-04-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19875-04-8, name is 2-Methylpyrimidin-4(3H)-one, molecular formula is C5H6N2O, molecular weight is 110.11, as common compound, the synthetic route is as follows.
(b) 11 g of 2-methyl-4-pyrimidone were introduced into 50 ml of phosphorus oxychloride, and the mixture was heated at 80 C. until a clear solution was produced. Excess phosphorus oxychloride was removed by distillation in vacuo, and the residue was poured into ice-water. While cooling, the solution was neutralized with potassium hydroxide solution and extracted with dichloromethane. The organic extracts were dried (Na2 SO4) and concentrated in vacuo, and column chromatography resulted in 8 g of 4-chloro-2-methylpyrimidine (melting point 50-60 C.).
Statistics shows that 19875-04-8 is playing an increasingly important role. we look forward to future research findings about 2-Methylpyrimidin-4(3H)-one.
Reference:
Patent; Hoechst Aktiengesellschaft; US4956366; (1990); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia