With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.153435-63-3, name is 2-(Tributylstannyl)pyrimidine, molecular formula is C16H30N2Sn, molecular weight is 369.1328, as common compound, the synthetic route is as follows.SDS of cas: 153435-63-3
6.01.15.01 4-H droxy-4-pyrimidin-2-yl-piperidine-l -carboxylic acid tert-butyl ester 9.9 mL 1.6 mol/L n-buthyllithium solution in hexane was added to 3.85 g 2-tributyl stannanyl- pyrimidine at -78 C. The reaction was stirred 30 min. at -78 C and 2.1 g 1- carboxylic acid tert- butyl ester-4-piperidone in 10 mL THF was added. The reaction mixture was warmed up and stirred at RT over night. Then, the reaction was cooled to 0 C, water and subsequently EtOAc were added and the layers were seperated. The organic layer was washed with water and with a saturated ammonia chloride solution. Then, the organic layer was dried and evaporated. The residue was purified by HPLC to yield 448 mg of the desiered product. Rt: 1.21 min (method B), (M+H)+: 280
At the same time, in my other blogs, there are other synthetic methods of this type of compound,153435-63-3, 2-(Tributylstannyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WELLENZOHN, Bernd; WO2013/83741; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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