Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 205672-25-9, name is 4-Amino-5-bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below., HPLC of Formula: C4H3BrClN3
A solution of 5-bromo-2-chioropyrimidin-4-amine (650 mg, 3.12 mmol), tert-butyl (4-methylpiperidin-4-yl)carbamate (835 mg, 3.90 mmol), and 4-methylmorpholine(411 tL, 3.74 mmol) in NMP (6.25 mL) was stirred in amicrowave reactor for 90 mm at 130 C. The resultingresidue was poured into water (100 mL) and was stirred atRT for 5 mm. The solid formed was filtered oil and driedunder high vacuum for 16 h to give tert-butyl (1 -(4-amino-5-bromopyrimidin-2-yl)-4-methylpiperidin-4-yl)carbamate(880 mg, 2.28 mmol). MS mlz 387.3 (M+H).
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Reference:
Patent; NOVARTIS AG; Chen, Zhuoliang; Dore, Michael; Fortanet, Jorge Garcia; Karki, Rajesh; Kato, Mitsunori; LaMarche, Matthew J.; Perez, Lawrence Blas; Williams, Sarah; Sendzik, Martin; (63 pag.)US2017/1975; (2017); A1;,
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