In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 23002-51-9, name is 6-Chloro-1H-pyrazolo[3,4-d]pyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines
A mixture of 6-chloro-1H-pyrazolo[3,4-djpyrimidine (1.25 g, 8.09 mmol), pyridinium ptoluene sulfonate (203 mg, 0.81 mmol) and 3,4-dihydro-2h-pyran (1.36 g, 16.17 mmol) indichloromethane (25 mL) was heated at reflux for 6 h and concentrated under reduced pressure. Theresidue was purified by column chromatography (silica gel, 100-200 mesh, 0 to 40% ethyl acetate inpetroleum ether) to afford 6-chloro- 1 -tetrahydropyran-2-yl-pyrazolo [3 ,4-djpyrimidine (1.8 g, 93%)as a white solid. 1H NMR(400 MHz, CDCl3) d 9.10 – 8.99 (m, 1H), 8.26 – 8.14 (m, 1H), 6.13 – 5.98 (m, 1H), 4.21 – 4.09 (m, 1H), 3.91 – 3.76 (m, 1H), 2.67 – 2.48 (m, 1H), 2.59 – 2.48 (m, 1H), 2.21 – 2.09 (m, 1H), 2.00 – 1.91 (m, 1H), 1.86 – 1.75 (m, 2H), 1.70 – 1.60 (m, 1H).
The synthetic route of 23002-51-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; PATEL, Snahel; (77 pag.)WO2019/204537; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia