Application of 3001-72-7 , The common heterocyclic compound, 3001-72-7, name is 2,3,4,6,7,8-Hexahydropyrrolo[1,2-a]pyrimidine, molecular formula is C7H12N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: In a pressure-resistant container equipped with a stirrer,162 parts (0.89 mol) of triethyl phosphate (manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) (A-1)130 parts (1.78 mol) of diethylamine (manufactured by BASF) (B-1) were charged, and the temperature was raised to 125 C. The reaction was allowed to continue for 30 hours with stirring. After cooling, the P-NMR of the reaction solution was measured. As a result, the peak of triethyl phosphate disappeared and only the peak of diethyl phosphate appeared. 260 parts (0.9 mol) of a methanol solution of 1,2,3,4-tetramethylimidazolium methyl carbonate (J-1) was added to this reaction solution for salt exchange. This solution was concentrated under reduced pressure at 100 C. using a rotary evaporator to obtain a yellow-brown solid. It was confirmed by 1 H-NMR and P-NMR that this yellowish brown solid was 1,2,3,4-tetramethylimidazolium diethylphosphate (K-1). In Example 1, 260 parts of a 1,2,3,4-tetramethylimidazolinium methyl carbonate salt methanol solution was changed to 112 parts ((0.9 mol)) of 1,5-diazabicyclo [4.3.0] -5-nonene (E-1 ), a yellow brown liquid was obtained in the same manner as in Example 1. It was confirmed by 1 H-NMR and P-NMR that this yellow-brown solid was 1,5-diazabicyclo [4.3.0] -5-nonenium diethyl phosphate (F-1).
The synthetic route of 3001-72-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SANYO CHEMICAL INDUSTRIES LIMITED; SHIRAISHI, ATSUSHI; (21 pag.)JP5647820; (2015); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia