Adding a certain compound to certain chemical reactions, such as: 5466-43-3, 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine, blongs to pyrimidines compound. Recommanded Product: 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine
Example 22. Preparation of Compound Nos. 142, 142a and 142b Step 3. To a solution of 2,4-dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine (1.5 g, 7.90 mmol) in isopropanol (15 mL) was added Nu,Nu-diisopropylethyl amine (2.18 mL, 12.64 mmol) followed by 5-(tert-butyl)-lH-pyrazol-3-amine (1.32 g, 9.48 mmol). The reaction mixture was refluxed at 100 C for 16 h. The reaction mixture was concentrated under vacuum to get oily residue which was diluted with water (50 mL) and extracted with ethyl acetate (2×50 mL). The combined organic layers were washed with water (3×60 mL) and dried over anhydrous sodium sulfate. Removal of solvent afforded solid crude was triturated with ether (20 mL) to get N-(5-(tert-butyl)-lH-pyrazol-3-yl)-2-chloro-6,7-dihydro-5H- cyclopenta[d]pyrimidin-4-amine (720 mg, 31.44%).
The synthetic route of 5466-43-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MEDIVATION TECHNOLOGIES, INC.; CHAKRAVARTY, Sarvajit; RAI, Roopa; GREEN, Michael, John; ANSARI, Amantullah; AGARWAL, Anil, Kumar; (216 pag.)WO2016/3827; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
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