Electric Literature of 31462-58-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.31462-58-5, name is 5-Iodopyrimidine, molecular formula is C4H3IN2, molecular weight is 205.9845, as common compound, the synthetic route is as follows.
General procedure: A mixture of parthenolide (1.0mmol) and an appropriate aromatic iodide (1.1mmol) was refluxed at 80C using palladium (II) ferrocene (0.01mmol) and di-isopropylethyl-amine (3.0mmol) in toluene (0.1ml) under air for 18-24h. The reaction mixture was then allowed to cool to room temperature, water (8ml) added, and the resultant mixture was extracted with ethyl acetate (10ml×3). The separated organics were dried over Na2SO4, filtered and the filtrate concentrated under reduced pressure. The obtained crude residue was purified by silica flash chromatography (9:1 to 4:1, hexanes/EtOAc) to afford the corresponding aryl substituted parthenolide as a solid (40-50mg) in 70-80% yield.
Statistics shows that 31462-58-5 is playing an increasingly important role. we look forward to future research findings about 5-Iodopyrimidine.
Reference:
Article; Penthala, Narsimha R.; Bommagani, Shobanbabu; Janganati, Venumadhav; Macnicol, Kenzie B.; Cragle, Chad E.; Madadi, Nikhil R.; Hardy, Linda L.; Macnicol, Angus M.; Crooks, Peter A.; European Journal of Medicinal Chemistry; vol. 85; (2014); p. 517 – 525;,
Pyrimidine | C4H4N2 – PubChem,
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