Reference of 33097-13-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33097-13-1, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.
In a glove box, to 2.36 g of 4,6-dichloro-2-(methylthio)pyrimidine-5- carbonitrile in 500 mL of 1 4-dioxane was added 2.82 g of phenylboronic acid, 14.70 g of potassium phosphate, 60 mg of palladium (II) acetate, then 141 mg of triphenylphosphine. The reaction was refluxed undernitrogen for 2.25 hours, cooled to room temperature, and then concentrated by rotary evaporation. Water was added and the contents were extracted with dichloromethane. The combined organic layers were dried over sodium sulfate, filtered, and concentrated by rotary evaporation to give a solid which was triturated with 45 mL of a 2:1 mixture of methyltert-butyl ether:dichloromethane, then washed with methyl tert-butyl ether to give Intermediate I as a tan solid (2.25g, 65% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,33097-13-1, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; HOWARD JR, Michael Henry; HLAING, Htay Min; HOSTETLER, Greg A.; KONDAKOV, Denis Yurievich; DOBBS, Kerwin D.; (87 pag.)WO2017/210075; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia