Electric Literature of 3764-01-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3764-01-0, name is 2,4,6-Trichloropyrimidine, molecular formula is C4HCl3N2, molecular weight is 183.42, as common compound, the synthetic route is as follows.
Synthetic method: 2,4,6-trichloropyrimidine (10.0 g, 54.97 mmol) was added to a 50 mL reaction flask, and CH2Cl2 (100 mL) was dissolved.DIPEA (57.72 mmol, 10.36 mL) was added and cooled to -5 ¡ã C then morpholine (54.97 mmol, 4.79 g).The reaction solution was reacted at a low temperature for 0.5 h, and then warmed to room temperature for 2 h.After the TLC reaction was completed, H 2 O (100 mL) was added, and the CH 2 Cl 2 layer was separated, and the aqueous phase was extracted once with CH 2 Cl 2 (100 mL).The organic layers were combined and washed once with saturated NaCl (100 mL).Dry with anhydrous Na2SO4.The solvent was evaporated under reduced pressure to give a crude product.Column chromatography purification (PE / EtOAc = 4 / 1) afforded white white solid: 8.43 g, yield: 65.81percent;
Statistics shows that 3764-01-0 is playing an increasingly important role. we look forward to future research findings about 2,4,6-Trichloropyrimidine.
Reference:
Patent; Guizhou Medical University; Zhang Jiquan; Li Shumin; Xu Xiaoqian; Wu Tingting; Tang Lei; (34 pag.)CN108191837; (2018); A;,
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