Share a compound : 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,71149-52-5, 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71149-52-5, name is 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C7H6ClN3, molecular weight is 167.6, as common compound, the synthetic route is as follows.Recommanded Product: 71149-52-5

To a solution of 4-chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine (400 mg, 2.4 mmol) in dichloromethane (10 mL) was added N-iodosuccinimide (537 mg, 2.39 mmol).The mixture was stirred at room temperature for 2 hours, then washed with aqueous sodium sulfite solution, dried over sodium sulfate, filtered, and concentrated in vacuo to provide the product as a brown solid. Yield: 330 mg, 1.12 mmol, 47%. LCMS m/z 293.8 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,71149-52-5, 4-Chloro-2-methyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; GALATSIS, Paul; HAYWARD, Matthew Merrill; HENDERSON, Jaclyn; KORMOS, Bethany Lyn; KURUMBAIL, Ravi G; STEPAN, Antonia Friederike; VERHOEST, Patrick Robert; WAGER, Travis T.; ZHANG, Lei; WO2014/1973; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia