Electric Literature of 56843-79-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 56843-79-9, name is 4-Chloro-2-methylthieno[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
A clear solution of 4-chloro-2-methylthieno[2,3-djpyrimidine (30 mg, 0.l62mmol), 4,4,4- trifluorobutylamine (55 tL, 0.486 mmol), DIEA (35 tL, 0.20 mmol), and dry p-dioxane (0.5 mL) was heated at 140 C for 90 minutes in a microwave reactor. A yellow solution formed, which was partitioned between DCM and water. The DCM layer was separated and set aside, and the aqueous layer was washed with ethyl acetate. Both organic layers were combined and concentrated undervacuum to afford a viscous yellow substance, which was lyophilized for 2 hours to give the final product(37 mg, 83% yield). LC-MS analysis indicated the desired product with >97% purity and mass: m/z 276(M+H). Calcd for C11H12F3N3S=275.29. 1H NMR (400MHz, DMSO-d6) oe 7.87 (t, J = 5.4 Hz, 4 H), 7.53(d, J = 5.9 Hz, 5 H), 7.43 (d, J = 5.9 Hz, 1 H), 3.60 – 3.51 (m, 10 H), 2.43 (s, 3 H), 2.40 -2.30 (m, 9 H),1.93 – 1.74 (m, 10 H).
According to the analysis of related databases, 56843-79-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SAINT LOUIS UNIVERSITY; WASHINGTON UNIVERSITY; MEYERS, Marvin, J.; SINGH, Megh; STALLINGS, Christina, L.; WEISS, Leslie, A.; WILDMAN, Scott; ARNETT, Stacy, D.; (134 pag.)WO2019/18359; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia