Adding a certain compound to certain chemical reactions, such as: 15846-19-2, 4-Chloro-6-methoxypyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H6ClN3O, blongs to pyrimidines compound. HPLC of Formula: C5H6ClN3O
[Reference Example 1]; 4-Chloro-N-(4-chloro-6-methoxy-5-pyrimidinyl)-3-nitrobenzamide; 4-Chloro-3-nitrobenzoic acid (30.2 g, 150 mmol) was suspended in ethyl acetate (150 mL), and thionyl chloride (22 mL, 300 mmol) was added to the resulting suspension. The suspension was then heated under refluxing for 5 hours. The reaction mixture was concentrated under reduced pressure. The residue was concentrated utilizing two portions of dry benzene and two portions of dichloromethane. The resulting acid chloride was dissolved in dichloromethane (20 mL), and the resulting solution was added to a solution of 5-amino-4-chloro-6-methoxypyrimidine (16.0 g, 100 mmol) in dichloromethane (100 mL). The resulting mixture was heated under refluxing for 16 hours. The heated mixture was then cooled to room temperature, and the precipitated crystalline product was collected by filtration and washed with four portions of dichloromethane (20 mL), to obtain 34.3 g (yield 100%) of the titled compound as a white crystalline product. 1H-NMR (CDCl3) delta : 4.07 (3H, s), 7.35 (1H, s), 7.74 (1H, d, J=8Hz), 8.08 (1H, dd, J=2Hz, 8Hz), 8.42 (1H, d, J=2Hz), 8.55 (1H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15846-19-2, 4-Chloro-6-methoxypyrimidin-5-amine, and friends who are interested can also refer to it.
Reference:
Patent; Nippon Chemiphar Co., Ltd.; EP1757610; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia