Reference of 409346-71-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 409346-71-0 name is 6-Bromo-3-ethyl-2-methoxyquinoline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example A; 2a.).Prepaj:ation.of interrnediate.6; nBuLi 1.6M in hexane (0.0382 mol) was added dropwise at -60C under N2 flow to amixture of 6-bromo-3-ethyl-2-methoxy- quinoline (0.03 mol) in THF (50ml). Themixture was stirred at -60C for 1 hour. A solution of 2,3-dihydro-l,4-benzodioxin-6-carboxaldehyde (0.0361 mol) in TBDF (50ml) was added dropwise. The mixture was20 stirred at -60C for 2 hours, then at -40C for 1 hour, poured out into water andammonium hydroxide and extracted with DCM. The organic layer was separated, dried(MgSO4), filtered and the solvent was evaporated. The product was used withoutfurther purification, yielding 10.56g of intermediate 6.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromo-3-ethyl-2-methoxyquinoline, and friends who are interested can also refer to it.