Reference of 4318-56-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4318-56-3, name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, molecular formula is C5H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(1) adding toluene to the reaction vessel, stirring is started, and then 6-chloro-3-methyluracil is sequentially added,2-cyano-5-fluorobenzyl bromide and tri-n-butylamine, the mixture was heated to 80 C under stirring, and the reaction was kept for 6 h. The reaction was monitored by TLC (petroleum ether: ethyl acetate = 3:2). After the -3-methyluracil is consumed, it is regarded as the end point of the reaction. After the reaction is completed, the purified water is added to the reaction vessel, the temperature is lowered to 20 C, stirred for 0.5-1 h, filtered, and the filter cake is washed twice with isopropyl alcohol to collect the filter. Cake, dried at 50 CDrying for 12h, the brownish yellow solid intermediate, intermediate 1; wherein the molar ratio of 6-chloro-3-methyluracil, 2-cyano-5-fluorobenzyl bromide and tri-n-butylamine is 1:1.1 :1.5;
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4318-56-3, 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione.
Reference:
Patent; Sichuan Xinsidun Pharmaceutical Co., Ltd.; Du Feng; Bai Xiao; (9 pag.)CN108822080; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia