Reference of 6299-25-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine, molecular formula is C5H4Cl2N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[00230] Reagents[00231] Experimental procedure:? ; Take ammonia in THF into a 2 L autoclave and add 4, 6-dichloro-2-(Methylthio) pyrimidine slowly.? Heat the reaction mixture to 50-60 C and maintain the reaction at 50-60 C for 3-4 hours (Inbuilt pressure 7- 8 Kg/cm ).? Check the progress of the reaction by TLC. Upon completion, the reaction was brought to 25-35 C.? Concentrate the reaction mixture under vacuum.? Charge Hexane and stir for 30-45 minutes at 25-35 C.? Filter the solid and wash the solid with Hexane.? Wash the solid with water (2X400 mL).? Dry the solid at 25-35 C till M.C reaches to less than 2%.Yield 352.0 g% of Yield: 97.77%.Purity by HPLC: 99.07%.Other suitable conditions such as ammonia in MeOH or dioxane could be used accordingly when different analogs are used. Example 1- 2. Preparation of 4-Amino-6-chloro-2- meth lthio)pyrimidine, 6.1
According to the analysis of related databases, 6299-25-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KINAGEN, INC.; MURPHY, Eric, A.; CHERESH, David, A.; ARNORD, Lee, Daniel; WO2011/97594; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia