In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3974-16-1, name is 4,6-Dichloro-5-phenylpyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 4,6-Dichloro-5-phenylpyrimidine
A suspension of 237 mg (1.0 mmol) of the bis hydrochloride salt of the step A compound of Example 127 (225 mg, 1.0 mmol) of 4,6-dichloro-5-phenylpyrimidine, and 276 mg (2 mmol) of K2CO3 in 5 mL of diglyme was heated at 150 C. for 30 min. The solution was cooled, diluted with MeOH and water, and purified by preparative HPLC (as described for the title compound of Example 1) to yield 0.480 mg of the desired compound as a bis TFA salt; MS: m/z 354 (M+H)+.
The synthetic route of 3974-16-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bristol-Myers Squibb Company; US6887870; (2005); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia