Application of 49845-33-2 ,Some common heterocyclic compound, 49845-33-2, molecular formula is C4HCl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 5 g (25 mmol) 2,4-dichloro-5-nitro-pyrimdine in 150 mL EtOAc was added 50 mL 28-34% aqueous NH4OH. After stirred at rt for 1 hour, the reaction mixture was filtered. The organic layer was concentrated to give desired solid product. 1H NMR (CD3OD): 9.03 (1H, s). LC-MS [M+H]=175.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 49845-33-2, 2,4-Dichloro-5-nitropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zhu, Song; US2005/250779; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia