Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100130-05-0, name is 5-Amino-2-(methylthio)pyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., name: 5-Amino-2-(methylthio)pyrimidine-4-carboxylic acid
EXAMPLE VI 4-Hydroxy-6-methylthiopyrimido[5,4-d]pyrimidine A mixture of 69 g of 5-amino-2-methylthiopyrimidine-4-carboxylic acid, 155 g of formamidine acetate and 300 ml of ethoxyethanol is heated to boiling for 2 hours. The reaction mixture is then cooled to 10 C., 250 ml of water are added, and the mixture is left to stand at 10 C. for one hour. It is then filtered with suction, washed with water and dried. Yield: 59 g (82% of theory), Melting point: >240 C., Rf: 0.63 (silica gel; methylene chloride/ethyl acetate/methanol=10:4:3). The following compound is obtained in analogy to Example VI:
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Reference:
Patent; Dr. Karl Thomae GmbH; US5977102; (1999); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia