Electric Literature of 3438-61-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3438-61-7, name is 5-Amino-4-methylpyrimidine, molecular formula is C5H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-benzyloxymethyl– isoxazole-3-carboxylic acid (0.24g, 1.0mmol), 5- amino-4-methylpyrimidine (0.13g, 1.2mmol), 1- hydroxybenzotriazole (0.01 g, 0.1mmol) was added to the chloroform (amylene addition of goods) (2.5mL). To the mixture, it was added at room temperature 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.24 g, 1.2 mmol), and stirred for 3 hours at 50 C.. Then, water was added to the reaction mixture, and the mixture was extracted twice with chloroform. After removing impurities through the organic layer to a short column which was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, represented by the following formula N-(4- methyl-pyrimidin-5-yl) -5-benzyloxymethyl – isoxazole-3-carboxamide (hereinafter, the present invention compound (39) referred to.) was obtained 0.16g.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3438-61-7, 5-Amino-4-methylpyrimidine.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; MITSUDERA, HIROMASA; OKAJIMA, MAYUMI; AWASAGUCHI, KENICHIRO; UJIHARA, KAZUYA; (111 pag.)JP2016/30727; (2016); A;,
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