Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5018-41-7, name is 4-Amino-6-chloro-5-methoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 5018-41-7
6-(4-(1 -(2-(azetidin-1 -yl)ethyl)-4-(2-(thfluoromethyl)Dvhdin-4-yl)-1 H-imidazol-2- yl)piperidin-1 -yl)-5-methoxypyrimidin-4-amine (“1 15”) A reaction mixture of 6-Chloro-5-methoxy-pyrimidin-4-ylamine (45.00 mg; 0.28 mmol; 1 .00 eq.), 4-[1 -(2-Azetidin-1 -yl-ethyl)-2-piperidin-4-yl-1 H-imidazol-4-yl]-2- trifluoromethyl-pyridine hydrochloride (4) (148.13 mg; 0.28 mmol; 1 .00 eq.), and Cs2C03 (367.53 mg; 1 .13 mmol; 4.00 eq.) in DMSO 1 .0ml was stirred at 120C for 2days, purified by HPLC collected title compound 17mg. LC-MS: (M+1 = 503, obsd. = 503).
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Reference:
Patent; MERCK PATENT GMBH; LAN, Ruoxi; HUCK, Bayard R.; CHEN, Xiaoling; XIAO, Yufang; DESELM, Lizbeth Celeste; QIU, Hui; NEAGU, Constantin; BANKSTON, Donald; JONES, Christopher Charles Victor; WO2013/40059; (2013); A1;,
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