Adding a certain compound to certain chemical reactions, such as: 50270-27-4, 2,4,6-Trichloropyrimidine-5-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 50270-27-4, blongs to pyrimidines compound. category: pyrimidines
To a solution of 2,4,6-trichloropyrimidine-5-carbaldehyde (3.50 g, 16.6 mmol) in THF (50 mL)was added N2H4.H20 (830 mg, 16.6 mmol) slowly at-lO °C. Then, Et3N (2.51 g, 24.9 mmol)was added to the mixture at -10 00. The mixture was stirred at -10 °C for 30 mm. The mixture was concentrated. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to give the title compound (1.25 g, yield 40percent) as a yellow solid. 1H NMR (300 MHz, CDCI3): 611.61 (brs, 1H), 8.25 (s, IH).LCMS [mobile phase: 5-95percent CH3CNJ: Rt = 2.005 mm;MS Calcd: 188; MS Found: 189 [M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,50270-27-4, its application will become more common.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; DING, Xiao; JIN, Yun; LIU, Qian; REN, Feng; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; WANG, Hailong; XING, Weiqiang; ZHAN, Yang; ZHAO, Baowei; (573 pag.)WO2017/12576; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia