Application of 588-36-3 ,Some common heterocyclic compound, 588-36-3, molecular formula is C6H9N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The mixture of intermediate compound 1 (14.6 mmol) and activated MnQ2 (80.0 mmol) in CH2C12 (200 mL) was stirred at room temperature for 6 h. After filtering off the black solid, the resulting intermediate aldehyde 2 wasdissolved in CH3OH (100 mL). The NaOMe (15.0 mmol) and 1- cyclopropylethan-1-one (16.0 mmol) were added at room temperature. The reaction mixture was allowed to react at reflux for 4 h. The resulting mixture was evaporated, dissolved in water, extracted with EtOAc, and purified by column chromatography to afford intermediate product 3 (65 % yield for steps).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,588-36-3, its application will become more common.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; FENG, Yangbo; LOGRASSO, Philip; ZHENG, Ke; PARK, Chul Min; WO2015/84936; (2015); A1;,
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