Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 31058-83-0, name is 6-Chloro-N,N-dimethylpyrimidin-4-amine. A new synthetic method of this compound is introduced below., Computed Properties of C6H8ClN3
To a solution of N- (cis-4-amino-cyclohexyl)-3, 4-difluoro-benzamide (442 mg) was added (6-chloro-pyrimidin-4-yl)-dimethyl-amine obtained in step A of example 1 (250 mg). The mixture was stirred at 180C for 8 hr in a sealed tube. To the mixture was added saturated aqueous NaHC03 and the aqueous layer was extracted with CHCl3 (three times). The combined organic layer was dried over MgS04, filtered, concentrated under reduced pressure, and purified by flash chromatography (NH-silica gel, 33% to 50% EtOAc in hexane and silica gel, 3% MeOH in CHCI3) to give N-(cis-4-{[6- (dimethylamino) pyrimidin-4-yl] amino} cyclohexyl)-3, 4-difluorobenzamide. To a solution of the above material in EtOAc (10 mL) was added 4 M hydrogen chloride in EtOAc (0.2 mL). The mixture was stirred at ambient temperature for 1 hr and concentrated under reduced pressure. The residue was suspended in Et2O (20 mL) and the suspension was stirred at ambient temperature for 4 hr. The precipitate was collected by filtration, washed with Et2O, and dried at 70C under reduced pressure to give N-(cis-4-{[6- (dimethylamino) pyrimidin-4-yl] amino} cyclohexyl)-3, 4-difluorobenzamide hydrochloride (99 mg). ESI MS m/e 398, M (free) +Na+ ;’H NMR (300 MHz, CDCI3) 8 1.69-2. 15 (m, 8 H), 3.00- 3.42 (m, 6 H), 3.69-3. 81 (m, 1 H), 4.03-4. 21 (m, 1 H), 5.26 (s, 1 H), 6.66-6. 80 (m, 1 H), 7.13-7. 26 (m, 1 H), 7.51-7. 62 (m, 1 H), 7.68-7. 80 (m, 1 H), 8.01 (s, 1 H), 8.68-8. 91 (m, 1 H), 13.84-14. 09 (m, 1 H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 31058-83-0, 6-Chloro-N,N-dimethylpyrimidin-4-amine.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc; WO2005/95357; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia