Application of 60186-89-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 60186-89-2 as follows.
To a suspension of 4-bromo-2,6-dimethoxypyrimidine (Intermediate A) (10.3 g, 46.8 mmol) and sodium hydrogen carbonate (NaHCCh) (5.51 g, 65.6 mmol) in MeOH/H20 (1 : 1, 120 mL) at room temperature was added bromine (4.34 mL, 84.2 mmol). The reaction mixture was stirred at room temperature for 1.5 hours. The mixture was diluted with dichloromethane (DCM) (100 mL) and the layers were separated. The aqueous phase was extracted with DCM (2 x 30 mL). The organic extracts were combined, filtered through a phase separator cartridge and concentrated in vacuo. The crude product was purified by chromatography on silica gel (220 g, 0-10% EtOAc in isohexane, gradient elution) to afford the title compound 4,5-dibromo-2,6-dimethoxypyrimidine (8.48 g, 60%) as a pale orange solid. Analytical data: Rl 2.24 min (Method 1); m/z 297/299/301 (M+H)+ (ES+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60186-89-2, its application will become more common.
Reference:
Patent; CORCEPT THERAPEUTICS INCORPORATED; HUNT, Hazel; CREPIN, Damien Francis Philippe; HILL-COUSINS, Joseph Thomas; BAKER, Thomas Matthew; DUFFY, Lorna; (0 pag.)WO2019/236487; (2019); A1;,
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