Application of 62802-42-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62802-42-0, name is 2-Chloro-5-fluoropyrimidine, molecular formula is C4H2ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0642] Synthesis of 5-fluoropyrimidine-2-carbonitrile: [0643] To a stirred solution of 2-chloro-5-fluoropyrimidine (280 mg, 2.11 mmol) in DMA (6 mL) under argon atmosphere were added zinc cyanide (161 mg, 1.37 mmol), Pd2(dba)3 (77 mg, 0.08 mmol), dppf (93 mg, 0.16 mmol) and zinc (32 mg, 0.50 mmol) at room temperature; heated to 100 C and stirred for 20 min under Micro Wave irradiation. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was diluted with water (30 mL) and extracted with EtOAc (2 x 45 mL). The combined organic extracts were washed with water (40 mL), dried over sodium sulphate, filtered and concentrated in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 7% EtOAc/ Hexanes to afford 5-fluoropyrimidine-2-carbonitrile (60 mg, 23%) as an off- white solid. [0644] 1H-NMR (CDC13, 400 MHz): delta 8.73 (s, 2H); TLC: 10% EtOAc/ Hexanes (R 0.4).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 62802-42-0, 2-Chloro-5-fluoropyrimidine.
Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia