In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. Recommanded Product: 6299-25-8
Example 2C4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid; To a solution of diisopropylamine (20 mL, 142 mmol) in tetrahydrofuran (170 mL) at -78C was added n-butyl lithium (55.4 mL, 2.5M solution in hexane, 138 mmol). The mixture was stirred at -78C for 1 hour and was charged with a solution of the product of Example 2B (18 g, 92.3 mmol) in tetrahydrofuran (40 mL). After stirring at -78C for 3 hours, dry carbon dioxide was bubbled into the mixture for 30 minutes, followed by the addition of water at low temperature. The mixture was allowed to warm to ambient temperature and the mixture was adjusted to pH = 1 by addition of 2M hydrochloric acid. The mixture was extracted with ethyl acetate (3 x 300 mL) and the combined organic layers were dried over sodium sulfate, filtered and concentrated. The residue was washed with toluene to obtain the title compound. MS: 239 (M+H+).
The synthetic route of 6299-25-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; WU, Fengchun; SHEN, Yan; LIU, Cuihua; ZOU, Zhenguang; WO2012/97478; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
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