Synthetic Route of 63200-54-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
Compound 1 (435 mg, 2.3 mmol), methyl o-aminobenzoate (419 mg, 2.7 mmol) were dissolved in 10 mL tertbutanol.To the solution was added trifluoroacetic acid (0.256 mL, 3.45 mmol). The resulting reaction liquid was heatedin 85C oil bath with stirring until compound 1 was reacted completely (LC-MS tracking). The reaction was stopped. Tothe reaction liquid was added 40 mL of saturated sodium bicarbonate solution, and the liquid was separated. The organicphase was washed twice with saturated sodium chloride solution, dried over anhydride sodium sulfate, concentratedand purified by silica-gel column chromatography (dichloromethane/methanol) to yield compound 4 (white solid, 424mg, yield 61%), which was used directly for the reaction in next step.MS (ESI) m/z: 303 [M+H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63200-54-4, 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine.
Reference:
Patent; Xiamen University; DENG, Xianming; ZHUANG, Zhongji; DENG, Zhou; HUANG, Xiaoxing; LIU, Yan; ZHANG, Ting; HUANG, Wei; XU, Qingyan; HU, Zhiyu; (86 pag.)EP3290420; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia