Electric Literature of 6972-27-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6972-27-6, name is 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.
General procedure: A mixture of (18a) (69 mg, 0.176 mmol), 6-chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione (61 mg, 0.35 mmol) and diisopropylethylamine (0.152 mL, 0.880 mmol) in isopropyl alcohol (0.5 mL) was heated at 80 C for 7 h. The reaction mixture was diluted with ethyl acetate, washed with satd NaHCO3 and brine, dried over NaSO4, and the solvent was removed under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane, and then MeOH/CHCl3) to give methyl 2-(11-(3-(4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazin-1-yl)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate (87 mg, 93% yield) as amorphous.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6972-27-6, its application will become more common.
Reference:
Article; Kubota, Katsumi; Kurebayashi, Hirotaka; Miyachi, Hirotaka; Tobe, Masanori; Onishi, Masako; Isobe, Yoshiaki; Bioorganic and Medicinal Chemistry; vol. 19; 9; (2011); p. 3005 – 3021;,
Pyrimidine | C4H4N2 – PubChem,
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