The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 916420-27-4, name is tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. name: tert-Butyl 2,4-dichloro-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate
Step 1- tert-butyl 2-chloro-4-(pyridin-4-yl)-5,6-dihydropyrido[3,4-d]pyrimidine- 7(8H)-carboxylate (ij): 4-(Tributylstannyl)pyridine (247 mg, 0.671 mmol), t-butyl 2,4- dichloro-5,6-dihydropyrido-[3,4-d]pyrimidine-7(8H)-carboxylate (bx) (200 mg, 0.6 mmol) and tetrakis(triphenylphosphine)palladium(0) (76 mg, 0.066 mmol) were dissolved in 1,4- Dioxane (7 mL). The reaction was micro waved at 1300C for 20 minutes The reaction mixture was concentrated on silica gel and purified by flash chromatography (100% Hex to 80% EtOAc/Hex) to give compound ij as a white solid: LC/MS: m/z = + 347.8 (M +H)+.
With the rapid development of chemical substances, we look forward to future research findings about 916420-27-4.
Reference:
Patent; GENENTECH, INC.; BERGERON, Philippe; COHEN, Frederick; ESTRADA, Anthony; KOEHLER, Michael, F. T.; LAU, Kevin, Hon Luen; LY, Cuong; LYSSIKATOS, Joseph, P.; ORTWINE, Daniel, Fred; PEI, Zhonghua; ZHAO, Xianrui; WO2010/14939; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia