Application of 157335-93-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 5; The t-butyl carbamate from step 4 (685 mg, 1.12 mmol) in CH2CI2 (6 mL) was treated with TFA (3 mL) under the conditions of step 5 of example 1. After the workup the crude free amine was taken up in MeCN (3 mL) was treated with the pyrimidine 5 (136mg, 1.54 mmol), EDCI (296 mg, 1.54 mmol), HOBt (208 mg, 1.54 mmol) and iPrNEt (0.532 mL, 3.0 mmol) under the conditions described in step 6 of example 1. The amide product (190 mg, 27%) after purification by flash chromatography (gradient 1: 9 to 2: 3 acetone/hexanes) as a clear oil. The HCI salt of this product was formed by the addition of 4N HCI (dioxane) followed by evaporation. HRMS calc for C36H44F2N503 (MH+) : 632.3412 ; found: 632.3442.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 157335-93-8, 4,6-Dimethylpyrimidine-5-carboxylic acid.
Reference:
Patent; SCHERING CORPORATION; WO2005/42517; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia