As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 720-01-4, name is Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate, molecular formula is C8H6ClF3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 720-01-4
(3,5-Bis-trifluoromethyl-ben2yl)-(5-morpholin-4-yl-pyrimidin-2-yl)-[2- (4 , 4 , 5 , 5 -tetramethyl- [ 1 , 3 , 2] dioxaborolan- 2 -yl) – 5 – trifluoromethyl-benzyl] – amine (250mg) is dissolved in 1,4-dioxane (5ml) and thereto are added ethyl 4-chloro-2-trifluoromethyl-pyrimidine-5-carboxylate (140mg), [I5 I1- bis(diphenylphosphino)ferrocene]dichloropalladium dichloromethane complex (30mg) and cesium carbonate (177mg), and the mixture is stirred under nitrogen atmosphere at 80C overnight. The reaction solution is cooled to room temperature, and thereto are added water and ethyl acetate and the insoluble materials are removed by filtration through Celite. The filtrate is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography (hexane : ethyl acetate = 9: 1-?4: 1) to give ethyl 4-(2-{[(3,5-bis- trifluoromethyl-benzyl) – (5-morpholin-4-yl-pyrimidin-2 -yl) -amino] -methyl}- 4-trifluoromethyl-phenyl)-2-trifluoromethyl-pyrimidine-5-carboxylate (199mg). MS (m/z): 783 [M+H]+.
With the rapid development of chemical substances, we look forward to future research findings about 720-01-4.
Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2007/88996; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia