Adding a certain compound to certain chemical reactions, such as: 1207518-63-5, Methyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1207518-63-5, blongs to pyrimidines compound. name: Methyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
Example 44; (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanol (44.1); To a suspension of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid methyl ester (example 43) (1.0 g, 4.716 mmol) in dichloromethane (60.0 mL) cooled to -780C, is added a solution of DIBAL-H (1.0 M in toluene, 14.15 mL, 14.15 mmol) dropwise. The resulting solution is stirred at -780C for 2 h and then at room temperature until TLC analysis indicates complete consumption of intermediate 43.2 (3 h). The reaction is quenched with aqueous NH4CI and stirred for 10 min. The salts separated are filtered off and the filtrate is washed with water, brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The crude residue is impregnated over silica gel using methanol and the impregnated silica gel is loaded onto a silica gel column. Elution with a solvent gradient of CH2CI2 : MeOH = 90: 10 followed by evaporation of the eluted solvent gives intermediate 44.1 as a brown solid. 1H NMR (400 MHz, CDCI3): delta 12.35 (brs, 1 H), 8.54 (s, 1 H), 7.54 (s, 1 H), 5.01 (t, J = 5.07 Hz, 1 H), 4.75 (d, J = 5.07 Hz, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1207518-63-5, its application will become more common.
Reference:
Patent; NOVARTIS AG; CHEN, Yen-Liang; DURAISWAMY, Jeyaraj; KONDREDDI, Ravinder Reddy; YIN, Zheng; WO2010/15637; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
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