Related Products of 883231-23-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.883231-23-0, name is N-Boc-2-Amino-5-bromopyrimidine, molecular formula is C9H12BrN3O2, molecular weight is 274.11, as common compound, the synthetic route is as follows.
A mixture of tert-butyl (5-bromopyrimidin-2-yl) carbamate (17a) (360 mg, 0.96 mmol) , N, N-dimethylpiperidin-4-amine (246 mg, 1.92 mmol) , Pd2 (dba) 3 (44 mg, 0.048 mmol) , Xantphos (56 mg, 0.096 mmol) , t-BuONa (184 mg, 1.92 mmol) in toluene (11 mL) was heated at 110 for 18 h under N2. The mixture was cooled to room temperature and concentrated in vacco. The residue was purified by chromatography on silica gel eluting with DCM /MeOH (10: 1) to give tert-butyl (5- (4- (dimethylamino) piperidin-1-yl) pyrimidin-2-yl) carbamate (17b) . MS-ESI (m/z) : 322 [M + 1] +.
The chemical industry reduces the impact on the environment during synthesis 883231-23-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; CHONGQING FOCHON PHARMACEUTICAL CO., LTD.; SHANGHAI FOCHON PHARMACEUTICAL CO., LTD.; ZHAO, Xingdong; LI, Tongshuang; ZHANG, Huajie; LI, Zhifu; LIU, Bin; LIU, Qihong; TAN, Rui; RONG, Yue; YANG, Lijun; CHEN, Zhifang; TAN, Haohan; JIANG, Lihua; LIU, Yanxin; LINGHU, Li; LIN, Min; SUN, Jing; WANG, Weibo; (89 pag.)WO2017/114351; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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