Synthetic Route of 25940-35-6 ,Some common heterocyclic compound, 25940-35-6, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(Benzotriazol-1 -yloxy)tripyrrolidinophosphonium hexafluorophosphate (1 .05 g, 2.02 mmol) was added to a mixture of pyrazolo[1 ,5-a]pyrimidine-3-carboxylic acid (299 mg, 1 .84 mmol, GAS No. 25940-35-6), trans-4-am ino-N-(2-chloro-4-fluorophenyl)cyclohexanecarboxam idehydrochloride (620 mg, 2.02 mmol) and N-ethyl-N-isopropylpropan-2-amine (1.6 ml, 9.2 mmol) in 20 ml N,N-dimethylformamide and the mixture was stirred over night at room temperature. For work-up, the reaction mixuture was concentrated under reduced pressure and the residue was stirred with a mixture of water and methanol. The precipitate was collected by filtration, washed with water and methanol and dried to yield the title compound(525mg, 68% yield).LG-MS (Method 1): R = 1 .01 mm; MS (ESIpos) m/z = 416.3 [M+H].1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 9.51 (5, 1H), 9.38-9.28 (m, 1H), 8.88-8.76 (m, 1H),8.58 (5, 1H), 7.85-7.75 (m, 1H), 7.66-7.57 (m, 1H), 7.54-7.43 (m, 1H), 7.32-7.18 (m, 2H),3.91-3.67 (m, 1H), 2.12-2.01 (m, 2H), 2.01-1.89 (m, 2H), 1.67-1.49 (m, 2H), 1.47-1.27 (m,2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25940-35-6, its application will become more common.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
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