Synthetic Route of C5H14Cl2N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Piperidin-4-amine dihydrochloride, is researched, Molecular C5H14Cl2N2, CAS is 35621-01-3, about Putrescine or spermidine binding site of aminopropyltransferases and competitive inhibitors. Author is Shirahata, Akira; Morohohi, Toru; Fukai, Masayo; Akatsu, Sakae; Samejima, Keijiro.
A model of the active site of aminopropyltransferases was proposed based on the study of a number of monoamino and diamino compounds as potential inhibitors and substrates, resp., of spermidine synthase purified from pig liver. The active site seems to have a relatively large hydrophobic cavity adjacent to a neg. charged site, to which a protonated amino group of putrescine binds, with another amino group of putrescine being situated in the hydrophobic cavity as a free form to be aminopropylated by decarboxylated S-adenosylmethionine. On the basis of the above-mentioned model, another modified one was proposed for spermine synthase, and several compounds designed according to the modified model were found to potently inhibit spermine synthase, purified from rat brain, in competition with spermidine. The newly developed inhibitors were about two orders of magnitude more potent in vitro than a known inhibitor of spermine synthase, dimethyl(5′-adenosyl)sulfonium perchlorate.
If you want to learn more about this compound(Piperidin-4-amine dihydrochloride)Synthetic Route of C5H14Cl2N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(35621-01-3).
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia