Rapid and ultra-trace levels analysis of 33 antibiotics in water by on-line solid-phase extraction with ultra-performance liquid chromatography-tandem mass spectrometry was written by Shen, Fei;Xu, Yan-Juan;Wang, Ye;Chen, Jing;Wang, Shuo. And the article was included in Journal of Chromatography A in 2022.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide This article mentions the following:
A method was developed for the determination of 33 antibiotics belonging to 4 different antibiotic groups, including sulfonamides (16), fluoroquinolones (12), macrolides (1), and tetracyclines (4) in water samples using online solid-phase extraction-ultra performance liquid chromatog.-electrospray ionization tandem mass spectrometry (online SPE-UPLC-MS/MS). The enrichment and anal. conditions were optimized for the determination of trace concentrations (nanogram per L). Aliquots of the water samples (5 mL) were filtered through a membrane and enriched on an online polymeric column with hydrophilic-lipophilic balance (HLB). The analyte was eluted by the mobile phase during online SPE and separated on an Acquity BEH130 column, detected by tandem mass spectrometry, and quantified using an external standard method. The optimization of the anal. methods was discussed, which included optimization of pH of the sample, filtration membrane, Na2EDTA, chromatog. column, formic acid and aqueous ammonia in mobile phase. The detection limit for all test compounds by this method was in the range of 0.2-1.5 ng/L, with recoveries of 76.6-118%. The precision of the method, as indicated by the relative standard deviation, was 2.4-7.9%. Results of anal. of surface water samples demonstrated the ability of the proposed method to analyze ultra-trace levels of antibiotics, without the need for complex manual pretreatment. In the experiment, the researchers used many compounds, for example, 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide).
4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide (cas: 1220-83-3) belongs to pyrimidine derivatives. The pyrimidine nitrogenous bases are derived from the organic compound pyrimidine through the addition of various functional groups. Pyrimidine derivatives have been used in a wide variety of pharmaceuticals including general anesthetics, anti-epilepsy medication, anti-malaria medication, drugs for treating high blood pressure, and HIV medication.Recommanded Product: 4-Amino-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia