Shih, Chuan; Gossett, L. S. published the artcile< The synthesis of N-{2-amino-4-substituted [(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acids as antineoplastic agents>, Computed Properties of 84955-32-8, the main research area is neoplasm inhibitor aminopyrrolopyrimidinylethylbenzoylglutamic acid; pyrrolopyrimidine folate antagonist antitumor; LY 231514 analog neoplasm inhibitor.
A variety of 4-substituted pyrrolo[2,3-d]pyrimidine based folate antagonists, e.g. I (R = Cl, H, OMe, NH2, SH, NEt2) which are closely related to the novel thymidylate synthase inhibitor LY231514 were prepared 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine (II; R = Cl, R1 = R2 = H) was selected as an important precursor for the preparation of key intermediates such as II (R = Cl, OMe, NEt2, NHCH2Ph, R1 = iodo, CCH, R2 = Me3CCO) (III). Pyrrolopyrimidines III were coupled with either 4-ethynylbenzoylglutamate or 4-iodobenzoylglutamate in a Pd-catalyzed Heck reaction to provide the basic skeleton of the targeted mols. The availability of the chlorine atom allowed the efficient introduction of different substituents at the 4-position of the pyrrolopyrimidine ring. In vitro anal. demonstrated that some I are highly cytotoxic against human leukemic cells (CCRF-CEM) in culture.
Heterocycles published new progress about Antitumor agents. 84955-32-8 belongs to class pyrimidines, and the molecular formula is C7H8N4O, Computed Properties of 84955-32-8.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia