Shiragami, Makoto published the artcileFormation of diastereomers of 5,6-dihydrothymine-6-sulfonate by deamination of 5-methylcytosine with bisulfite, Safety of 5-Methylcytosinehydrochloride, the main research area is methylcytosine bisulfite deamination stereo; thymine methylcytosine deamination; cytosine bisulfite deamination kinetics.
The bisulfite-mediated deamination of 5-methylcytosine yielded a diastereomeric mixture of 5,6-dihydrothymine-6-sulfonate. One of the diastereomers was identical with the thymine-bisulfite adduct formed by treatment of thymine with bisulfite, and was assigned the structure in which the H at pos. 5 and the sulfonate at pos. 6 are trans. The rates of degradation of this adduct was stable at pH 6.9, the half life being 13 hr at 37°, whereas at pH 8.9 it degrades with a half life of 70 min. The other diastereomer, in which the 5-H and 6-SO3- are cis was stable in mildly alk. conditions. This isomer rapidly generated thymine at pH 13.8.
Chemical & Pharmaceutical Bulletin published new progress about Deamination kinetics. 58366-64-6 belongs to class pyrimidines, name is 5-Methylcytosinehydrochloride, and the molecular formula is C5H8ClN3O, Safety of 5-Methylcytosinehydrochloride.
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia