Pyrimidines. XLII. Synthesis of 2- and 6-substituted 4-fluoropyrimidines was written by Shkurko, O. P.;Baram, S. G.;Mamaev, V. P.. And the article was included in Izvestiya Sibirskogo Otdeleniya Akademii Nauk SSSR, Seriya Khimicheskikh Nauk in 1973.Reference of 51421-99-9 This article mentions the following:
4-Fluoropyrimidines I (R = H, Me Ph, OMe, CF3, F, NMe2, R1 = Me, H, Ph, F, MeO, NH2, NMe2) were prepared in 10-97% yields by fluorination of the corresponding chloropyrimidines by CsF in DMF or methylpyrrolidone and by nucleophilic substitution of a F atom in difluoro- and trifluoro- pyrimidines. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-methoxypyrimidine (cas: 51421-99-9Reference of 51421-99-9).
4-Chloro-2-methoxypyrimidine (cas: 51421-99-9) belongs to pyrimidine derivatives. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. We all know its importance to life – pyrimidine and purine bases are included in the structure of DNA and RNA.Reference of 51421-99-9
Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia