The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10244-24-3, name is 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine
The 4,4 ‘ – (6-chloro-pyrimidine -2,4-diyl) two morpholine (301 mg, 1 . 06mmol), 7-bromo-8 – (trifluoromethyl) – 3,4-dihydro -2H-pyrido [3,2-b] [1,4] oxazine (200 mg, 0 . 71mmol),were taken and then duplex pinacone borate (350 mg, 1 . 38mmol), cesium fluoride (500 mg, 3 . 3mmol), palladium acetate (20 mg, 0 . 09mmol) and butyl b (1-adamantyl) diphenylphosphinobiphenyl (64 mg, 0 . 18mmol), were sequentially added to the toluene and methanol (4 ml, 1:1) in the mixed solvent, and added to the above mentioned solution, under nitrogen protection,at 70 C oil bath for 1 hour. After the reaction, concentrating, separating TLC (petroleum ether: ethyl acetate = 1:2), to obtain the title compound (45 mg, yield 14%).
With the rapid development of chemical substances, we look forward to future research findings about 10244-24-3.
Reference:
Patent; Shandong Xuan Bamboo Pharmaceutical Technology Co., Ltd.; Wu, Yong qian; (49 pag.)CN105461714; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia