Related Products of 1044767-99-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1044767-99-8, name is 5-Bromo-4-chloropyrimidin-2-amine. A new synthetic method of this compound is introduced below.
Step a: 5-bromo-4-chloropyrimidine-2-amine (2) (370.27 mg, 2.94 mmol), and 2-furancarbohydrazide (3a) (300 mg, 1.44 mmol), dissolved in 10 mL n-butanol At 120 C under nitrogen, the reaction was refluxed for 12 hours, concentrated under reduced pressure to remove the solvent, and subjected to silica gel column chromatography (CH2Cl2: MeOH = 10: 1) to obtain N ‘-(2-amino-5-bromopyrimidin-4-yl ) furan-2-carbohydrazide (4a)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1044767-99-8, 5-Bromo-4-chloropyrimidin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; Fudan University; Chang Jun; Wang Meiling; Jin Lin; Zhang Heyanhao; Niu Tong; (9 pag.)CN111018858; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia