Electric Literature of 1211443-61-6, Adding some certain compound to certain chemical reactions, such as: 1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide,molecular formula is C14H17ClN4O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1211443-61-6.
Under nitrogen, 2-chloro-7-cyclopentyl–N,N- dimethyl -7H- pyrrolo [2,3-d] pyrimidine-6-carboxamide (125mg, 0.43mmol), 4-(5 -Amino-pyrazine-2-carbonyl)piperazine-1-carboxylate (150mg, 0.60mmol, cesium carbonate (300mg, 0.92mmol),BINAP (70mg, 0.11mmol), palladium acetate (25mg, 0.11mmol)was dissolved in 1,4-dioxane (35mL) was stirred and heated to 110 , reaction 13h. Completion of the reactionAfter the reaction was cooled to roomtemperature, filtered through Celite, and the filtrate was concentrated underreduced pressure and the solvent was distilled off, the residue was separatedby column chromatography (methylene chloride / methanol (V / V)= 10/1) to give a pale yellow solid (140mg,64.86%)
According to the analysis of related databases, 1211443-61-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Zhang, Yingjun; Nie, Linlin; Bai, Shun; Zheng, Changchun; Nie, biao; Li, Zhiyong; Tan, Yumei; (61 pag.)CN105294737; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia