Synthetic Route of 145783-15-9 ,Some common heterocyclic compound, 145783-15-9, molecular formula is C7H9Cl2N3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
23.80 g of 4,6-dichloro-2-propylthio-5-aminopyrimidine was added to the reaction flask.51.7 g of N,N-diisopropylethylenediamine, 9.36 g of cyclopentylamine and 200 ml of DMF,Stir and heat to 90 C, TLC control reaction is complete, cooled to room temperature,The reaction solution was poured into 100 ml of cold water and extracted with ethyl acetate (30 ml ¡Á 3).The organic phase was dried over anhydrous magnesiumYield 24.38 g of a nearly brown solid III-1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common.
Reference:
Patent; Tianjin Pharmaceutical Institute Co., Ltd.; Liu Bingni; Liu Dengke; Zhi Shuang; Shang Qian; (19 pag.)CN109516990; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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