Reference of 1546-78-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1546-78-7 as follows.
Take 0.17g (0.001mol) 4- hydroxy-6-trifluoromethyl-pyrimidine (prepared as described in Example 1), 0.23g (0.001mol) 4- chloro-1- (4-chlorophenyl) -1H – pyrazole (prepared as in Example 2), 0.14g (0.001mol) of potassium carbonate in 50ml single neck flask, 10mlN, N- dimethylformamide as a solvent, was heated to 100 deg.] C, the reaction 4-10 hours, TLC after completion of the reaction was monitored, the solvent was distilled off under reduced pressure, was added (3 × 50ml) and extracted with ethyl acetate, the organic phase was washed with saturated brine 50ml, after solvent removal the residue by column chromatography (eluent, ethyl acetate and petroleum ether , a volume ratio of 1: 2) to obtain 0.26 g of a white solid, yield 72.5%,
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1546-78-7, its application will become more common.
Reference:
Patent; Shenyang Sinochem Agrochemicals R&D Co., Ltd.; Sun, Xufeng; Guan, Aiying; Zhao, Jie; Ma, Sen; Sun, Qin; Chen, Xuanming; Liu, Zhangling; (40 pag.)CN105777717; (2016); A;,
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