Application of 19646-07-2 , The common heterocyclic compound, 19646-07-2, name is 2,4-Dichloro-5-methoxypyrimidine, molecular formula is C5H4Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 2,4 dichloro-5-methoxypyrimidine (0.45g, 2.5mmol) and ammonia in methanol (2N, 20ml) was stirred at room temperature overnight. The mixture was then concentrated in vacuo and washed with water. The residue was purified by column chromatography (20- 60percent ethyl acetate/ petroleum ether) to furnish the title compound as a white solid (211 mg). MS: [M+H]+ = 160
The synthetic route of 19646-07-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTEX THERAPEUTICS LIMITED; ASTEX THERAPEUTICS LIMITED; WO2009/150240; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia