Adding a certain compound to certain chemical reactions, such as: 111196-81-7, 2-Chloro-5-ethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111196-81-7, blongs to pyrimidines compound. Computed Properties of C6H7ClN2
Step B: Preparation of 4-((lr,4r)-4-((l-(5-Ethylpyrimidin-2-yl)piperidin-4- yl)methoxy)cyclohexyl)-3-fluoro-N,N-dimethylbenzamide.; A mixture of 3-fluoro-N,N-dimethyl-4-(((lr,4r)-4-(piperidin-4- ylmethoxy)cyclohexyl)benzamide hydrochloride (14.0 mg, 0.035 mmol), prepared in Step A above, 2-chloro-5-ethylpyrimidine (20 mu, 0.165 mmol), and triethylamine (30 muEpsilon, 0.220 mmol) in iPrOH (1.3 mL) was heated under microwave irradiation at 120 C for 2 h. The mixture was purified by HPLC (5-95% CH3CN). Fractions containing the title compound were partly concentrated and the residue was extracted with 1M NaOH and CH2C12. The organic phase was dried over MgS04, filtered, and concentrated to give the title compound (10.2 mg, 0.022 mmol, 62.0% yield) as a white solid. Exact mass calculated for C27H37FN4O2: 468.2, found: LCMS m/z= 469.4 [M+H]+; lU NMR (400 MHz, CDC13) delta ppm 1.18 (t, = 7.6 Hz, 3H), 1.19-1.26 (m, 2H), 1.34-1.58 (m, 4H), 1.83-1.93 (m, 5H), 2.15-2.17 (m, 2H), 2.45 (q, = 7.6 Hz, 2H), 2.81- 2.91 (m, 3H), 2.99 (s, 3H), 3.09 (s, 3H), 3.23-3.30 (m, IH), 3.36 (d, = 5.8 Hz, 2H), 4.69-4.76 (m, 2H), 7.06-7.09 (m, IH), 7.12-7.14 (m, IH), 7.20-7.25 (m, IH), 8.16 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111196-81-7, its application will become more common.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; LEHMANN, Juerg; THORESEN, Lars; WO2012/135570; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia