Application of 90905-33-2, Adding some certain compound to certain chemical reactions, such as: 90905-33-2, name is 2-Methylpyrimidine-5-carbaldehyde,molecular formula is C6H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90905-33-2.
2-Methylpyrimidine-5-carbaldehyde (0.27 g, 2.21 mmol) was dissolved in EtOH (40 mL), and 4-acetylpyridine (0.57 mL, 0.62 g, 5 mmol) was added followed by crushed solid KOH (0.33 g, 5.90 mmol) after which the solution turned red. Aqueous NH3 (25percent in water, 13.9 mL, 90 mmol) was added dropwise and the mixture stirred overnight at ambient temperature. A yellow precipitate formed which was separated by filtration, washed with water (3 * 7 mL) and ethanol (3 * 7 mL) and recrystallized from chloroform/methanol. Compound 4 was obtained as a white solid (0.26 g, 0.78 mmol, 32percent). Decomposition > 260 °C. 1H NMR (500 MHz, CDCl3) ?/ppm 9.02 (s, 2H, HC4), 8.83 (m, 4H, HA2), 8.09 (m, 4H, HA3), 8.01 (s, 2H, HB3), 2.87 (s, 3H, HMe); 13C{1H} NMR (126 MHz, CDCl3) ?/ppm 169.3 (CC2), 155.9 (CA4), 155.14 (CC4), 150.8 (CB4) 150.7 (CA2), 145.3 (CB2), 128.5 (CC5), 121.1 (CA3), 118.3 (CB3), 25.9 (CMe); IR (solid, nu/cm-1) 3077 (w), 3033 (w), 1609 (m), 1594 (s), 1569 (m), 1549 (m), 1544 (m), 1539 (m), 1531 (m), 1464 (s), 1461 (s), 1456 (s), 1447 (m), 1432 (m), 1429 (m), 1423 (m), 1404 (m), 1377 (m), 1373 (m), 1368 (m), 1247 (m), 1064 (m), 1028 (m), 999 (m), 995 (m), 895 (m), 851 (m), 844 (m), 835 (s), 791 (m), 739 (m), 731 (m), 670 (m), 664 (m), 649 (m), 637 (s), 629 (s), 619 (m), 616 (m), 604 (m), 597 (m), 582 (m), 570 (m), 564 (m), 543 (m), 541 (m), 535 (m), 528 (m), 523 (m), 519 (m), 513 (s), 506 (s), 502 (s). UV-Vis (MeCN, 2.5 * 10-5 M) lambda/nm (epsilon/dm3 mol-1 cm-1) 247 (44 458), 312 (7856). ESI-MS m/z 326.3 [M+H]+ (calc. 326.1). Found: C, 69.04; H, 4.75; N, 20.22; required for C20H15N5.H2O C, 69.96; H, 4.99; N, 20.40.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90905-33-2, 2-Methylpyrimidine-5-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Maximilian Klein; Constable, Edwin C.; Housecroft, Catherine E.; Zampese, Jennifer A.; Polyhedron; vol. 81; (2014); p. 98 – 104;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia