In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2022-78-8, name is 5-Fluoropyrimidin-2(1H)-one, the common compound, a new synthetic route is introduced below. COA of Formula: C4H3FN2O
EXAMPLE 24 1-(3-Methylphenylthio)methyl-5-fluoropyrimidin-2-one 3-(Chloromethylthio)toluene (6.5 mmol) was added to a solution of 5-fluoropyrimidin-2-one (6.5 mmol) and triethylamine (6.5 mmol) in dichloromethane (75 ml) and the resultant mixture heated under reflux for 2 days. The solvent was then distilled off, the residue triturated with water and the residual material extracted with CCl4. Evaporation of the extracts and crystallisation of the residue from ethyl acetate gave the pure product; 0.40 g (25%), m.p. 124 C. (Found: C57.42; H4.63. Calc. for C12 H11 FN2 OS: C57.59; H4.43) 1 H NMR (DMSO d6); delta 2.28 (Me), 5.17(CH2), 7.2 (Ph), 8.05 (H-4), 8.70 (H-6). IR (KBr): 1670 cm-1 (CO), MS [70 eV, m/z (% rel. int.)]: 250 (8,M), 137(11), 136)36), 135(10), 128(7), 127(100), 100(34), 91(9).
The synthetic route of 2022-78-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nyegaard & Co. A.S.; US4596870; (1986); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia