A common compound: 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 213265-83-9
Into 3 ml of acetnitrile were added 0.2 g of 4, 6-DICHLORO-5-FLUOROPYRIMIDINE, 0.50 g of pottasium carbonate and 0.27 g of cis-2, 6-DLMETHYLHEXAHYDRO-LH-AZEPINE hydrochloride, and the mixture was stirred for 2 hours at 60 C. The reaction mixture was cooled to near room temperature, a saturated ammonium chloride aqueous solution was added therein, and the mixture was extracted with tert-butyl methyl ether three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.3 g of 1- (6-CHLORO- 5-fluoropyrimidin-4-yl) -cis-2, 6-DIMETHYLHEXAHYDRO-LH-AZEPINE H-NMR : 0.90-1. 04 (m, 4H involving a doublet at 0.95), 1.10-1. 32 (m, 4H), 1.36-1. 48 (m, 1H), 1.71-1. 90 (m, 3H), 2.04-2. 14 (M, 1H), 2.91 (brt, 1H), 3.70 (brs, 1H), 4.42-4. 82 (br, 1H) 8.09 (d, 1H) GC-MS: 257 (M+)
With the rapid development of chemical substances, we look forward to future research findings about 213265-83-9.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2004/99160; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia